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Methotrexate

   Methotrexate

CAS: 59-05-2

 

         Structure:

                     

 Specifications: Conforms to standard USP 27 and EP4,BP2002

Text USP27 EP4 BP2002
Assay% 98.0-102.0 98.0-102.0 98.0-102.0
Residue on ignition% ≤0.1    
Specific roataion +19-+24 +19-+24  
Loss on drying%      
Chromatographic purity% ≤2.0(total)    
  ≤0.5(individual)    
Water% ≤12.0 ≤13.0 ≤12.0
Organic Volatile impurites conforms
Sulphated ash%   ≤0.1 ≤0.1
Heavy metals ppm   50 1
Related substance      
Total   ≤1.3 ≤1.3%
Individual   At most five peaks At most five peaks
Impurity A%   ≤0.5 ≤0.5
Impurity B%   ≤0.5 ≤0.5
Impurity C%   ≤0.5 ≤0.5
Impurity D%   ≤0.5 ≤0.5
Impurity E%   ≤0.5 ≤0.5
Unknown Impurity %   ≤0.5 ≤0.5
(R)-Methotrexate%   ≤3.0 ≤3.0

 Physical properties:

Appearance: orange yellow crystal powders
Solubility: the production hardly dissolves in water, ethanol, chloroform or ether, and it easily dissolves in sparse alkali, and it can dissolve in dilute hydrochloric acid.

 USE: The product is used as anti-tumour medicament.

 Package: It's packed 2-ply polyethylene bags are heat sealed, Net weight 1KG/Tin.

 

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